Jiarui Ding

Broadly, my research lies at the interface between computing, mathematics, and biology. In modern biology, a biological system, such as a cell, is described by a few latent factors such as cell state and cell cycle stage, indirectly observed from noisy and potential high-dimensional measurements, which are typically confounded by a set of biological or technical batch vectors, where the data from one batch differ systematically from the data from another batch. I am interested in modeling these biological data, with knowledge from decades of biomedical research as prior information encoded in model structures, to uncover the interpretable latent factors.