Rosalía Aguirre-Hernández
James Hogg
iCAPTURE Centre
Vancouver, British Columbia
V6Z 1Y6
email: raguirre
[at] mrl [dot] ubc [dot] ca
phone: (604) 682-2344 ext. 62868
I am currently a postdoctoral fellow at the James Hogg iCAPTURE Centre in St Paul's
Hospital under the supervision of Dr. Keith Walley and Dr.
Mark
Wilkinson. My research interests include bioinformatics,
computational biology and clinical genomics. Currently, I’m working on
indentifying the genetic variants that predispose
an individual to susceptibility for inflammatory diseases and predict responses
to therapy. My research consists on developing a high throughput Whole Genome
Association methodology that efficiently identifies, in an unbiased way, many
genetic variants that influence important clinical outcomes of inflammatory
diseases.
For my PhD
thesis I improved the performance and scope of algorithmic methods for the
design of RNA strands that are predicted to fold to a given secondary
structure, according to a standard thermodynamic model. The design of RNA
structures is important for applications in therapeutics and nanotechnology. My
research consisted on investigating the empirical complexity of this problem,
on designing stable structures according to several parameters, and on
designing complexes of RNA molecules, that is, RNA molecules that interact with
each other. My PhD supervisors were Anne
Condon and Holger
Hoos. In April 2007, I defended my Ph.D.
thesis " Computational
RNA Secondary Structure Design: Empirical Complexity and Improved Methods".