Subject: | Ribozymes: recent advances in the development of RNA tools |
Presenter: | Rosalia Aguirre-Hernandez |
Paper: | " Ribozymes: recent advances in the development of RNA tools " |
  | by Puerta-Fernandez E, Romero-Lopez C, Barroso-delJesus A, Berzal-Herranz A. |
Abstract |
Ribozymes: recent advances in the development of RNA tools
The discovery 20 years ago that some RNA molecules, called ribozymes,
are able to catalyze chemical reactions was a breakthrough in biology.
Over the last two decades numerous natural RNA motifs endowed with
catalytic activity have been described. They all fit within a few
well-defined types that respond to a specific RNA structure. The
prototype catalytic domain of each one has been engineered to generate
trans-acting ribozymes that catalyze the site-specific cleavage of other
RNA molecules. On the 20th anniversary of ribozyme discovery we briefly
summarize the main features of the different natural catalytic RNAs. We
also describe progress towards developing strategies to ensure an
efficient ribozyme-based technology, dedicating special attention to
the ones aimed to achieve a new generation of therapeutic agents.
Reference:
Puerta-Fernandez E, Romero-Lopez C, Barroso-delJesus A, and Berzal-Herranz A.
(2003). Ribozymes: recent advances in the development of RNA tools.
FEMS Microbiol Rev. Apr; 27(1):75-97. Review.
The paper is available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12697343
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