Subject: | RNA Secondary Structures and Energy Models |
Presenter: | Mirela Andronescu |
Abstract |
RNA Secondary Structures and Energy Models
All current (best) approaches for RNA secondary structure
prediction from sequence are based on Turner's model, the best
available energy model, but which has limitations. We are
studying ways to improve RNA secondary structure prediction,
mainly by using a more realistic energy model. We are
formulating and studying three different problems: (1) designing
a stochastic local search algorithm for secondary structure
prediction which could use any energy model; (2) deriving
better rules of the model by analysing known structures and
by combining two different models from the literature; (3)
learning a set of unknown parameters of the model, which reflects
more closely our knowledge about secondary structures. |