Abstract |
Can we find the family trees, or pedigrees, that relate the haplotypes of a
group of individuals? Collecting the genealogical information for how
individuals are related is a very time-consuming and expensive process. Methods
for automating the construction of pedigrees could stream-line this
process. While constructing single-generation families is relatively easy given
whole genome data, reconstructing muti-generational, possibly inbred, pedigrees
is much more challenging.
I will present three methods for reconstructing multi-generational pedigrees: a
method for synthetic data, and two practical methods, one for outbred data and
one for inbred data. In contrast to previous methods that focused on the
independent estimation of relationship distances between every pair of
individuals, we designed methods that aim at the reconstruction of the entire
pedigree. Both practical methods out-perform the state-of-the-art and the
outbreeding method is capable of reconstructing pedigrees at least six
generations back in time with high accuracy.
If there is time, I will also discuss the computational complexity of
likelihood calculations on pedigree graphs. It turns out that from a
computational complexity perspective, haplotype data is no more helpful than
genotype data, even though haplotype data certainly provides more information
about inheritance.
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