Title: | Sequence Factors Influencing the Rate of Toehold Binding in the DNA Toehold Exchange Process |
Speaker: |
David Chan Department of Computer Science, University of British Columia |
Abstract |
With the dawn of nanotechnology, DNA is frequently used as engineering
material for constructing various nanomachines. Many such creations
rely on DNA strands undergoing a process called DNA Toehold Exchange,
where short dangles on DNA Complexes form toeholds allowing target DNA
strands to efficiently bind and displace the original
strands. However, the kinetics of this process are still not fully
understood, requiring much expensive trial-and-error and experimental
fitting of rate constants when designing such systems. As such, the
goal of research in this area is to better understand the factors
influencing the kinetics of this process to reduce the design
costs. |