Title: How microRNAs choose their targets, Ivo Hofacker, Nature Genetics 39, 1191 - 1192 (2007)
Speaker: Mirela Andronescu
Abstract The growing list of known microRNAs is only as useful as our ability to identify the mRNA targets they control. A new study stresses the role of messenger RNA structure in microRNA target recognition and suggests that binding of the RNA-induced silencing complex is largely controlled by the thermodynamics of RNA-RNA interactions.