Subject: Metabolic Pathways
Presenters: Sanja [1,2], Baharak [3]
Abstracts [1] An efficient algorithm for detecting frequent subgraphs in biological networks
Mehmet Koyutürk, Ananth Grama and Wojciech Szpankowski
Bioinformatics, Volume 20, suppl_1, Pp. i200-i207

Motivation: With rapidly increasing amount of network and interaction data in molecular biology, the problem of effectively analyzing this data is an important one. Graph theoretic formalisms, commonly used for these analysis tasks, often lead to computationally hard problems due to their relation with subgraph isomorphism.

Results: This paper presents an innovative new algorithm for detecting frequently occurring patterns and modules in biological networks. Using an innovative graph simplification technique, which is ideally suited to biological networks, our algorithm renders these problems computationally tractable. Indeed, we show experimentally that our algorithm can extract frequently occurring patterns in metabolic pathways extracted from the KEGG database within seconds. The proposed model and algorithm are applicable to a variety of biological networks either directly or with minor modifications.

[2] Conserved pathways within bacteria and yeast as revealed by global protein network alignment
Brian P. Kelley, Roded Sharan, Richard M. Karp, Taylor Sittler, David E. Root, Brent R. Stockwell and Trey Ideker
PNAS, September 30, 2003, vol. 100, no. 20, 11394-11399

We implement a strategy for aligning two protein-protein interaction networks that combines interaction topology and protein sequence similarity to identify conserved interaction pathways and complexes. Using this approach we show that the protein-protein interaction networks of two distantly related species, Saccharomyces cerevisiae and Helicobacter pylori, harbor a large complement of evolutionarily conserved pathways, and that a large number of pathways appears to have duplicated and specialized within yeast. Analysis of these findings reveals many well characterized interaction pathways as well as many unanticipated pathways, the significance of which is reinforced by their presence in the networks of both species.

[3] A Faster Algorithm for Detecting Network Motifs
Sebastian Wernicke
WABI 2005.

Motifs in a network are small connected subnetworks that occur in significantly higher frequencies than in random network. They have recently gathered much attention as a useful concept to uncover structural design principles of complex networks. Kashan et al. proposed a sampling algorithm for efficinetly performing the computationally chalenging task of detecting network motifs. However, among other drawbacks, this algorithm suffers from sampling bias and is only efficient when the motifs are small (3 or 4 nodes). Based on a detailed analysis of teh previous algorithm, we present a new algoirhtm for network motif detection which overcomes these drawbacks. Experiments on a testbed of biological networks show our algorithm to be ordrs of magnitude faster than previous approaches. This allows for the detection of larger motifs in bigger networks than was previously possible, facilitating deper insight into the field.