Subject: | Phylogentically and spatially conserved word pairs associated with gene-expression changes in yeasts |
Presenter: | Sanja Rogic |
Paper: | " Phylogenetically and spatially conserved word pairs associated with gene-expression changes in yeasts " |
  | by Chiang DY, Moses AM, Kellis M, Lander ES, Eisen MB |
Abstract |
Phylogenetically and spatially conserved word pairs associated with
gene-expression changes in yeasts
Background: Transcriptional regulation in eukaryotes often
involves multiple transcription factors binding to the same transcription
control region, and to understand the regulatory content of eukaryotic
genomes it is necessary to consider the co-occurrence and spatial
relationships of individual binding sites. The determination of conserved
sequences (often known as phylogenetic footprinting) has identified
individual transcription factor binding sites. We extend this concept of
functional conservation to higher-order features of transcription control
regions. Reference:
Chiang DY, Moses AM, Kellis M, Lander ES, Eisen MB. (2003).
Phylogenetically and spatially conserved word pairs associated with
gene-expression changes in yeasts.
Genome Biol. 4(7):R43. Epub 2003 June 26.
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