Subject: | Genetic Algorithms |
Presenter: | Mario Pineda |
Paper: | " The hotspot conversion paradox and the evolution of meiotic recombination. " |
  | by Boulton et al. |
Abstract |
The joys and perils of recombination - the hotspot conversion paradox and the evolution
of recombination
Studies of meiotic recombination have revealed an evolutionary paradox.
Molecular and genetic analysis has shown that crossing over initiates at
specifiec sites called hotspots, by a recombinational-repair mechanism in
which the initiating hotspot is replaced by a copy of its homolog. Under
this scenario active hotspot alleles will rapidly be replaced by inactive
alleles, which arise by mutations and increase by
recombination-associated gene conversion. A previous model (Boulton et
al, 1997 aka the BMR-model) have shown that neither the benefits of
accurate segregation nor those of recombining flanking genes are
sufficient to preserve the active alleles in the face of conversion.
Recent evidence from molecular studies have characterize recombinational
hotspots in greater detail and have significantly modified our view of
the molecular mechanism of recombination. We now know that hotspot
activity is regulated by one or several trans-acting modifier loci.
Futhermore, the hotspot sites are associated with structurally
compromised regions of the chromatin which are predominantly located in
promoter regions. We have revisited the BMR-model and incoporated this
new molecular evidence into a multilocus modifier model using a genetic
algorithm in an attempt to resolve the paradox.
Reference: Boulton et al. 1997. The hotspot conversion paradox and the
evolution of meiotic recombination. PNAS 94:8058-8063
The paper is available at http://penguin.zoology.ubc.ca/reprints/boulton_etal97.pdf
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